| L-脯氨酸催化下甲基酮和1-芳基-2,2,2-三氟乙酮的不对称Aldol反应 |
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| 引用本文： | 邱丽华,沈宗旋,石常青,刘艳华,张雅文.L-脯氨酸催化下甲基酮和1-芳基-2,2,2-三氟乙酮的不对称Aldol反应[J].中国化学,2005,23(5):584-588. |
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| 作者姓名： | 邱丽华 沈宗旋 石常青 刘艳华 张雅文 |
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| 作者单位： | KeyLaboratoryofOrganicSynthesisofJiangsuProvince,CollegeofChemistryandChemicalEngineering,SuzhouUniversity,Suzhou,Jiangsu215006,China |
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| 摘 要： | Direct asymmetric aldol addition of methyl ketones to 2,2,2-trifluoro-1-phenylethanone and its ring-substituted derivatives was achieved using L-proline as a chiral promoter. Various optically active β-trifluoromethyl-β-hydroxy ketones were obtained in almost quantitative yields with moderate enantioselectivities up to 64 % ee.
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| 关 键 词： | 脯氨酸 催化反应 不对称丁间醇醛反应 甲基酮 1-芳基-2 2 2-三氟乙基酮 |
| 收稿时间： | 2004-9-20 |
| 修稿时间： | 2005-1-24 |
Proline Catalyzed Asymmetric Aldol Reaction between Methyl Ketones and 1‐Aryl‐2,2,2‐trifluoroethanones |
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| Qiu Li‐Hua,Shen Zong‐Xuan,Shi Chang‐Qing,Liu Yan‐Hua,Zhang Ya‐Wen.Proline Catalyzed Asymmetric Aldol Reaction between Methyl Ketones and 1‐Aryl‐2,2,2‐trifluoroethanones[J].Chinese Journal of Chemistry,2005,23(5):584-588. |
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| Authors: | Qiu Li‐Hua Shen Zong‐Xuan Shi Chang‐Qing Liu Yan‐Hua Zhang Ya‐Wen |
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| Abstract: | Direct asymmetric aldol addition of methyl ketones to 2,2,2‐trifluoro‐1‐phenylethanone and its ring‐substituted derivatives was achieved using L‐proline as a chiral promoter. Various optically active β‐trifluoromethyl‐β‐hydroxy ketones were obtained in almost quantitative yields with moderate enantioselectivities up to 64 % ee. |
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| Keywords: | proline aldol addition 1‐aryl‐2 2 2‐trifluoroethanone |
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