Thermal behavior of verapamil hydrochloride and its association with excipients |
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Authors: | Ronaldo S Nunes Felipe S Semaan Alan T Riga Éder T G Cavalheiro |
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Institution: | 1.Departamento de Química e Física Molecular, Instituto de Química de S?o Carlos,USP,Sao Carlos,Brazil;2.Pharmacy Practice Department, College of Pharmacy,The University of Toledo,Toledo,USA |
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Abstract: | The thermal properties of verapamil hydrochloride (VRP) and its physical association as binary mixtures with some common excipients
were evaluated. Thermogravimetry (TG) was used to determine the thermal mass loss, as well as to study the kinetics of VRP
thermal decomposition, using the Flynn-Wall-Ozawa model. Based on their frequent use in pharmacy, five different excipients
(microcrystalline cellulose, magnesium stearate, hydroxypropyl methylcellulose, polyvinylpyrrolidone and talc) were blended
with VRP. Samples were prepared by mixing the analyte and excipients in a proportion of 1:1 (m/m). DSC curves for pure VRP
presented an endothermic event at 143 ± 2 °C (ΔHmelt = 132 ± 4 J g−1), which corresponds to the melting (literature Tm = 143.7 °C, ΔHmelt = 130.6 J g−1). Comparisons among the observed results for each compound and their binary physical mixtures presented no relevant changes.
This suggests no interaction between the drug and excipient. |
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