| Ru-catalyzed highly enantioselective hydrogenation of α-keto Weinreb amides |
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| 作者姓名： | ZHAO MengMeng LI WanFang MA Xin FAN WeiZheng TAO XiaoMing LI XiaoMing XIE XiaoMin ZHANG ZhaoGuo |
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| 作者单位： | School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University;Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences |
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| 基金项目： | supported by the National Natural Science Foundation of China (21172146) |
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| 摘 要： | Asymmetric hydrogenation of α-keto Weinreb amides has been realized with Ru((S)-Sunphos)(benzene)Cl]Cl as the catalyst and CeCl 3·7H2O as the additive.A series of enantiopure α-hydroxy Weinreb amides(up to 97% ee) have been obtained.Catalytic amount of CeCl3·7H2O is essential for the high reactivity and enantioselectivity and the ratio of CeCl3·7H2O to Ru((S)-Sunphos)(benzene)Cl]Cl plays an important role in the hydrogenation reaction.
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| 关 键 词： | asymmetric hydrogenation α-keto Weinreb amides CeCl3·7H2O |
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