| Synthesis of Peptoid Nucleic Acid with Thymine as Nucleic Base |
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| 作者姓名： | Yun WU Jie Cheng XU Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai |
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| 作者单位： | Yun WU; Jie Cheng XU Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032 |
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| 基金项目： | Authors thank the National NatUral Science Foundation of China for financial support !(29672047). |
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| 摘 要： | The sequence specific bonding of oligonucleotide to RNA or double stranded DNA hasattTacted wide attention as the antisense and antigene strategies for treatment of diseasesat the level of gene expression in medicinal chemistry'. Peptide nucleic acids designedas a chemira of nucleobases and polyamidic backbone bind with high affinity andsequence specifity to both comPlementary RNA and DNA and a number of templatefunctions are inhibited on forming PNAasA and PNA/DNA complex'-'. In the …
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Synthesis of Peptoid Nucleic Acid with Thymine as Nucleic Base |
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| Yun WU, Jie Cheng XU Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai .Synthesis of Peptoid Nucleic Acid with Thymine as Nucleic Base[J].Chinese Chemical Letters,2000,11(9). |
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| Authors: | Yun WU Jie Cheng XU |
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| Abstract: | The synthesis of peptoid nucleic acid bearing thymine as nucleobase has been achieved. This modified oligonucleotide showed good hybridization with DNA. |
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| Keywords: | Peptoid peptide nucleic acid solid phase synthesis thymine |
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