Sulpholane as a solvent for titration of barbiturates and sulpha drugs |
| |
| Authors: | Buxton T L Caruso J A |
| |
| Institution: | Department of Chemistry University of Cincinnati Cincinnati, Ohio 45221, U.S.A. |
| |
| Abstract: | Sulpholane (tetramethylenesulphone) has been used as the medium for non-aqueous potentiometric titration of barbiturates and sulpha drugs with tetrabutylammonium hydroxide. Recoveries for 0.1-0.3 mmole of barbituric acid, phenobarbital, amobarbital, barbital, secobarbital, sulphapyridine, sulphadiazine and sulphamerazine were generally in the range 99-101%. A glass-calomel electrode system was used: common acid-base indicators give no colour change in the medium used. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
