Synthetic studies of stereocalpin A and its C5-epimer: total synthesis of 11-epi- and 5,11-diepi-stereocalpin A |
| |
Authors: | K Mahender ReddyJ Shashidhar Gurava Reddy PottireddygariSubhash Ghosh |
| |
Institution: | CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| |
Abstract: | This Letter describes the synthetic studies of stereocalpin A and its C5-epimer. After various cyclization attempts, successful macrolactamization at 9-10 position was tried inorder to obtain stereocalpin A and its C5-epimer, which were accompanied by complete racemization and resulted in the synthesis of 11-epi- and 5,11-diepi-stereocalpin A. Highly functionalized octanoic acid motif of the depsipeptide was constructed by applying Paterson’s aldol methodology, owing to its diversity in synthesizing various analogs of aliphatic acid. |
| |
Keywords: | Stereocalpin A Antitumor Antidiabetic Paterson&rsquo s aldol Macrolactamization |
本文献已被 ScienceDirect 等数据库收录! |