Rosin Derivatives as a Platform for the Antiviral Drug Design |
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Authors: | Larisa Popova Olga Ivanchenko Evgeniia Pochkaeva Sergey Klotchenko Marina Plotnikova Angelica Tsyrulnikova Ekaterina Aronova |
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Institution: | 1.Graduate School of Biotechnology and Food Science, Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya Street 29, 195251 Saint Petersburg, Russia; (O.I.); (A.T.); (E.A.);2.Smorodintsev Research Institute of Influenza, Prof. Popov Street 15/17, 197376 Saint Petersburg, Russia; (S.K.); (M.P.) |
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Abstract: | The increased complexity due to the emergence and rapid spread of new viral infections prompts researchers to search for potential antiviral and protective agents for mucous membranes among various natural objects, for example, plant raw materials, their individual components, as well as the products of their chemical modification. Due to their structure, resin acids are valuable raw materials of natural origin to synthesize various bioactive substances. Therefore, the purpose of this study was to confirm the possibility of using resin acid derivatives for the drug design. As a result, we studied the cytotoxicity and biological activity of resin acid derivatives. It was shown that a slight decrease in the viral load in the supernatants was observed upon stimulation of cells (II) compared with the control. When using PASS-online modeling (Prediction of Activity Spectra for Substances), the prediction of the biological activity spectrum showed that compound (I) is capable of exhibiting antiviral activity against the influenza virus. The use of the SWISS-ADME webserver to reveal the drug-like properties of compounds did not directly indicate the presence of antiviral activity. These results indicate the potential of resin acid derivatives as a starting point for extensive research in the study of biological activity. |
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Keywords: | antibacterial activity antiviral activity biological activity cytotoxicity DAA fungicidal activity MTT assay PASS-online modeling SWISS-ADME web server |
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