Aqueous media preparation of 2-amino-4,6-diphenylnicotinonitriles using cellulose sulfuric acid as an efficient catalyst |
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| Authors: | Syed Sheik Mansoor Krishnamoorthy Aswin Kuppan Logaiya Prasanna Nithiya Sudhan Saleem Malik |
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| Institution: | 1. Bioactive Organic Molecule Synthetic Unit, Research Department of Chemistry, C. Abdul Hakeem College, Melvisharam, 632 509, Tamil Nadu, India
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| Abstract: | A convenient approach to the synthesis of 2-amino-4,6-diphenylnicotinonitriles via four-component reaction of aromatic aldehydes, acetophenone derivatives, malononitrile and ammonium acetate is described. The reactions were done in water as solvent using cellulose sulfuric acid as catalyst. This simple protocol offer advantages such as shorter reaction times, simple work-up procedure, excellent yields and catalyst recovery. |
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