Analytical investigations of poly(acrylic acid) coatings electrodeposited on titanium-based implants: a versatile approach to biocompatibility enhancement |
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Authors: | E De Giglio S Cometa N Cioffi L Torsi L Sabbatini |
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Institution: | (1) Department of Chemistry, University of Bari, Via E. Orabona 4, 70126 Bari, Italy |
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Abstract: | A polyacrylic acid film was synthesized on titanium substrates from aqueous solutions via an electroreductive process for
the first time. This work was done in order to develop a versatile coating for titanium-based orthopaedic implants that acts
as both an effective bioactive surface and an effective anti-corrosion barrier. The chemical structure of the PAA coating
was investigated by X-ray photoelectron spectroscopy (XPS). Scanning electron microscopy (SEM) was employed to evaluate the
effect of annealing treatment on the morphology of the coatings in terms of their uniformity and porosity. Inductively coupled
plasma mass spectrometry was used to measure ion concentrations in ion release tests performed on Ti-6Al-4V sheets modified
with PAA coatings (annealed and unannealed). Results indicate that the annealing process produces coatings that possess considerable
anti-corrosion performance. Moreover, the availability and the reactivity of the surface carboxylic groups were exploited
in order to graft biological molecules onto the PAA-modified titanium implants. The feasibility of the grafting reaction was
tested using a single aminoacid residue. A fluorinated aminoacid was selected, and the grafting reaction was monitored both
by XPS, using fluorine as a marker element, and via quartz crystal microbalance (QCM) measurements. The success of the grafting
reaction opens the door to the synthesis of a wide variety of PAA-based coatings that are functionalized with selected bioactive
molecules and promote positive reactions with the biological system interfacing the implant while considerably reducing ion
release into surrounding tissues.
Figure Vanadium release from bare Ti-6Al-4V sheets compared with the release from sheets coated with annealed and unannealed electrosynthesised
PAA
Dedicated to Professor P.G. Zambonin on the occasion of his 72nd birthday. |
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Keywords: | Titanium PAA Electrosynthesis Corrosion protection Biomaterial Surface modification |
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