| 高效液相色谱仪器系统对红霉素肟分析的影响 |
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| 引用本文： | 孙京国,姚国伟,欧育湘.高效液相色谱仪器系统对红霉素肟分析的影响[J].光谱学与光谱分析,2004,24(9):1148-1150. |
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| 作者姓名： | 孙京国 姚国伟 欧育湘 |
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| 作者单位： | 北京理工大学生命科学与技术学院,北京,100081;河北师范大学化学学院,河北,石家庄,050091;北京理工大学生命科学与技术学院,北京,100081;北京理工大学材料科学与工程学院,北京,100081 |
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| 基金项目： | 国家经贸委技术创新项目 (0 1BK 0 0 9)资助 |
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| 摘 要： | 探讨了日立HITACHIL 710 0高效液相色谱 (HPLC)、岛津LC 6A型液相色谱、WatersTM4 74液相色谱系统及相关色谱柱对红霉素肟及其相关物质的色谱条件影响 ,实验表明 ,在其他色谱条件相对稳定的条件下 ,不同型号仪器和色谱柱对样品分离度及保留时间有较大影响 ,摸索到了不同仪器系统下的稳定分析条件 ,取得了相对良好的线性相关性 ,对不同环境下进行红霉素肟的质量检测具有指导意义。
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| 关 键 词： | 高效液相色谱 色谱系统 红霉素肟 |
| 文章编号： | 1000-0593(2004)09-1148-03 |
| 修稿时间： | 2003年3月28日 |
Effect of High Performance Liquid Chromatographic Instrument System on the Analysis of Erythromycin A Oxime |
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| SUN Jing-guo ,YAO Guo-wei ,OU Yu-xiang . School of Life Science and Technology,Beijing Institute of Technology,Beijing ,China . Chemistry College of Hebei Normal University,Shijiazhuang ,China . School of Material Science and Engineering,Beijing Institute of Technology,Beijing ,China.Effect of High Performance Liquid Chromatographic Instrument System on the Analysis of Erythromycin A Oxime[J].Spectroscopy and Spectral Analysis,2004,24(9):1148-1150. |
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| Authors: | SUN Jing-guo YAO Guo-wei OU Yu-xiang School of Life Science and Technology Beijing Institute of Technology Beijing China Chemistry College of Hebei Normal University Shijiazhuang China School of Material Science and Engineering Beijing Institute of Technology Beijing China |
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| Institution: | School of Life Science and Technology, Beijing Institute of Technology, Beijing 100081, China. |
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| Abstract: | A HPLC chromatography for the determination of erythromycin A oxime and relative compounds was studied, amd the effect of chromatography systems including a HITACHI L-7100, a Shimadzu LC-6A, a Waters TM 474 and relative columns was analyzed. It was revealed that different HPLC apparatus and columns have obvious impact on the peak separation and retention time under the general chromatographic condition. The suitable chromatographic conditions for several different chromatography systems were summarized with good linear relationship, which is very significant to the quality control of erythromycin A oxime and relative compounds. |
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| Keywords: | HPLC Chromatographic Instrument Erythromycin A oxime |
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