| ICP-MS测定血中镁、铜、铅浓度时的基体效应单一内标校正方法研究 |
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| 引用本文： | 杨乐,曾静,王小燕,吴赞,池海涛,欧阳荔,张经华,王京宇. ICP-MS测定血中镁、铜、铅浓度时的基体效应单一内标校正方法研究[J]. 光谱学与光谱分析, 2010, 30(2): 518-522. DOI: 10.3964/j.issn.1000-0593(2010)02-0518-05 |
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| 作者姓名： | 杨乐 曾静 王小燕 吴赞 池海涛 欧阳荔 张经华 王京宇 |
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| 作者单位： | 北京大学公共卫生学院,北京,100191;北京大学公共卫生学院,北京,100191;北京大学医药卫生分析中心生命元素组学实验室,北京,100191;北京市理化分析测试中心,北京,100089 |
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| 基金项目： | 国家自然科学基金项目(30770654);;北京市自然科学基金项目(7062040)资助 |
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| 摘 要： | ICP-MS测定模拟全血基体中不同质量段的Mg, Cu, Pb元素,考察基体效应对测定值的影响,分别采用传统内标法和单一内标CAIS方法(common analyte internal standardization)对其进行校正和比较。结果表明CAIS方法适用于不同浓度血液基体中多种元素的同时校正,且效果良好,其相对平均误差仅为3.05%,明显低于传统内标法的12.39%和校正前的23.91%;CAIS方法不受内标元素和被测元素质量数差异、测定强度差异以及电极电位差异的限制;使用全血和血清标准物质对CAIS方法可靠性进行验证,测定值全部落在标准值范围内。
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| 关 键 词： | CAIS 基体效应 镁 铜 铅 |
| 收稿时间： | 2009-02-28 |
Simultaneous Correction for Blood Matrix Effect on Determination of Magnesium,Copper and Lead Concentration in Blood Samples by ICP-MS Using CAIS |
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| YANG Le,ZENG Jing,WANG Xiao-yan,WU Zan,CHI Hai-tao,OUYANG Li,ZHANG Jing-hua,WANG Jing-yu. Simultaneous Correction for Blood Matrix Effect on Determination of Magnesium,Copper and Lead Concentration in Blood Samples by ICP-MS Using CAIS[J]. Spectroscopy and Spectral Analysis, 2010, 30(2): 518-522. DOI: 10.3964/j.issn.1000-0593(2010)02-0518-05 |
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| Authors: | YANG Le ZENG Jing WANG Xiao-yan WU Zan CHI Hai-tao OUYANG Li ZHANG Jing-hua WANG Jing-yu |
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| Affiliation: | 1. School of Public Health, Peking University, Beijing 100191, China2. Laboratory of Biometallomics, Center of Medical & Health Analysis, Peking University, Beijing 100191, China3. Beijing Centre for Physical & Chemical Analysis, Beijing 100089, China |
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| Abstract: | The influence of matrix effect on the determination of magnesium,copper and lead in human blood matrix stimulant and its correction was studied by using both conventional internal reference method & common analyte internal standardization(CAIS).The obtained results indicate that CAIS method is applicable for simultaneous correction of multi-elements in blood matrix.The relative errors between the determined and the true values are 3.05%(by CAIS method),12.39%(by conventional internal reference correction) a... |
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| Keywords: | Common analyte internal standardization Blood matrix effect Magnesium Copper Lead |
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