Viral self-assembly as a thermodynamic process |
| |
Authors: | Bruinsma Robijn F Gelbart William M Reguera David Rudnick Joseph Zandi Roya |
| |
Institution: | Department of Physics and Astronomy, The University of California at Los Angeles, Los Angeles, California 90095-1569, USA. |
| |
Abstract: | The protein shells, or capsids, of nearly all spherelike viruses adopt icosahedral symmetry. In the present Letter, we propose a statistical thermodynamic model for viral self-assembly. We find that icosahedral symmetry is not expected for viral capsids constructed from structurally identical protein subunits and that this symmetry requires (at least) two internal "switching" configurations of the protein. Our results indicate that icosahedral symmetry is not a generic consequence of free energy minimization but requires optimization of internal structural parameters of the capsid proteins. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|