Calophyline A, a new rearranged monoterpenoid indole alkaloid from Winchia calophylla |
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Authors: | Li Li-Mei Yang Tai Liu Yang Liu Jin Li Min-Hui Wang Yan-Tang Yang Shu-Xia Zou Qiang Li Guo-You |
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Institution: | Research Center, Chengdu Medical College, Chengdu 610083, Sichuan, P. R. China. |
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Abstract: | Calophyline A (1), a novel unprecedented rearranged monoterpenoid indole alkaloid, along with a new natural product N-methyl aspidodasycarpine (2) and six known analogues, was isolated from the trunk barks of Winchia calophylla. The structure of compound 1 was elucidated on the basis of spectroscopic data and then confirmed by a single-crystal X-ray crystallographic analysis. A hypothetical biogenetic pathway for compound 1 was proposed. All isolated compounds were evaluated for their in vitro cytotoxicity against a small panel of human cancer cell lines. |
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