| 含己烷雌酚的聚磷酸酯的合成及其抗肿瘤活性研究 |
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| 引用本文： | 罗毅,卓仁禧.含己烷雌酚的聚磷酸酯的合成及其抗肿瘤活性研究[J].高等学校化学学报,1994,15(7):1090-1092. |
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| 作者姓名： | 罗毅 卓仁禧 |
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| 作者单位： | 武汉大学化学系 |
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| 摘 要： | 合成了３种主链含己烷雌酚的生物可降解的聚磷酸酯，结构经ＩＲ，＾１ＨＮＭＲ和元素分析鉴定，通过水接触角的测定研究了聚合物的亲水－疏水性能，以ｐＨ值变化表征了聚合物的体外水解速率。初步的体外实验表明，此类聚磷酸酯具有较好的体外抗艾氏腹水癌活性。
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| 关 键 词： | 己烷雌酚 聚磷酸酯 抗肿瘤活性 |
Synthesis and Antitumor Activity of Polyphosphate Ester Containing Hexestrol |
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| LUO Yi,ZHUO Ren-Xi,FAN Chang-Lie.Synthesis and Antitumor Activity of Polyphosphate Ester Containing Hexestrol[J].Chemical Research In Chinese Universities,1994,15(7):1090-1092. |
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| Authors: | LUO Yi ZHUO Ren-Xi FAN Chang-Lie |
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| Abstract: | Three biodegradable polyphosphate esters were synthesized by polycondensation of hexestrol with dichlorophosphoric acid ethyl ester,dichlorophosphonoformic acid ethyl ester or dichlorophosphonoacetic acid ethyl ester.The structures of these polymers were confirmed by IR,1H NMR and elementary analysis.The release testing was carried out in different pH media.The in vitro antitumor activity data showed that this kind of polyphosphate ester as polymeric prodrugs exhibits a good antitumor activity against EAC cells. |
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| Keywords: | Hexestrol Polyphosphate ester Antitumor activity |
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