New99mTc-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging |
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| Authors: | M S Jovanovi? J Brbori? S Vladimirov B Zmbova LJ Vuksanovi? D ?ivanov-Staki? V Obradovi? |
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| Institution: | (1) Laboratory for Radioisotopes, Vinča Institute of Nuclear Sciences, P. O. Box 522, 11001 Belgrade, Yugoslavia;(2) Faculty of Pharmacy, University of Belgrade, Yugoslavia;(3) Clinical Centre of Serbia, Institute of Nuclear Medicine, Belgrade, Yugoslavia |
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| Abstract: | A new diiodine substituted IDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with99mTc. It was established that99mTc-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on99mTc-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for99mTc-SOLCOIODIDA. Related to99mTc-SOLCOIODIDA,99mTc-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of99mTc-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of99mTc-SOLCOIODIDA has been reduced for about 60%. The protein binding of99mTc-DIIODIDA and99mTc-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that99mTc-DIIODIDA hepatobiliary imaging agent is superior to the presently used99mTc-monoiodine IDA derivatives. |
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