| Kinetics and mechanism of electron-induced splitting of a cyclobutane pyrimidine dimer with or without an electron acceptor |
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| 作者姓名： | 晏利琴 宋钦华 黑晓明 王文锋 郭庆祥 |
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| 作者单位： | Department of Chemistry，University of Science and Technology of China，Hefei 230026，China，Department of Chemistry，University of Science and Technology of China，Hefei 230026，China，Department of Chemistry，University of Science and Technology of China，Hefei 230026，China，Laboratory of Radiation Chemistry，Shanghai Institute of Nuclear Research，Chinese Academy of Sciences，Shanghai 201800，China，Department of Chemistry，University of Science and Technology of China，Hefei 230026，China |
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| 基金项目： | 国家自然科学基金，教育部博士基金 |
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| 摘 要： | DNA repair has received heightened attention in recent years as ozone depletion threatens to significantly increase DNA damage by UVB radiation1—6]. The major lesions formed in DNA by this radiation are cis-syn cyclobutane pyrimidine dimers, which are created by the linkage of two neighboring pyrimidine bases in DNA via C5-C5 and C6-C6 atoms by 2+2] cycloaddition2,5—8]. This potentially lethal or mutagenic damage can be repaired either by the removal of the damaged bases by excisio…
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Kinetics and mechanism of electron-induced splitting of a cyclobutane pyrimidine dimer with or without an electron acceptor |
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| Liqin?Yan,Qinhua?SongEmail author,Xiaoming?Hei,Wenfeng?Wang,Qingxiang?Guo.Kinetics and mechanism of electron-induced splitting of a cyclobutane pyrimidine dimer with or without an electron acceptor[J].Science in China(Chemistry),2003,46(5):439-444. |
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| Authors: | Liqin?Yan Email author" target="_blank">Qinhua?SongEmail author Xiaoming?Hei Wenfeng?Wang Qingxiang?Guo |
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| Institution: | 1. Department of Chemistry, University of Science and Technology of China, Hefei 230026, China
2. Laboratory of Radiation Chemistry, Shanghai Institute of Nuclear Research, Chinese Academy of Sciences, Shanghai 201800, China |
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| Abstract: | Utilizing a pulse radiolysis equipment with time-resolved optical detector, kinetic processes of electron-induced splitting of cis-syn 1,3-dimethyluracil cyclobutane dimer (DMUD) in aqueous solution were investigated in the presence or absence of riboflavin (RF) or flavin adenine dinucleotide (FAD). It has been observed that the cyclobutane pyrimidine dimer reacting with hydrated electron splits spontaneously to give a monomer and a monomer radical anion, and the anion transfers one electron to RF or FAD. From the buildup kinetics of radical species, the rate constants of electron transfer from the monomer radical anion to RF and FAD have been determined. On the basis of comparison of the interactions between DMUD and hydrated electron in the presence and absence of RF or FAD, a chain reaction process in the absence of RF or FAD has been demonstrated. |
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| Keywords: | cyclobutane pyrimidine dimer pulse radiolysis riboflavin flavin adenine dinucleotide electron transfer DNA photoreactivation |
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