An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis |
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| Authors: | Oliveira Jaim S Sousa Eduardo H S Basso Luiz A Palaci Moisés Dietze Reynaldo Santos Diógenes S Moreira Icaro S |
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| Institution: | Universidade Federal do Rio Grande do Sul, Departamento de Biologia Molecular e Biotecnologia, Av. Bento Gon?alves 9500, Porto Alegre, RS 91501-970, Brazil. labasso@dna.cbiot.ufrgs.br |
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| Abstract: | The in vitro kinetics of inactivation of both wild-type and I21V InhA enzymes by FeII(CN)5(INH)]3- indicate that this process requires no activation by KatG, and no need for the presence of NADH. This inorganic complex may represent a new class of lead compounds to the development of anti-tubercular agents aiming at inhibition of a validated target. |
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