Synthesis and Crystal Structure of （E）2-（3′-Bromo- 5′-chloro-salicylidene amino）-4-methyl Pyridine

A new Schiff base compound, 2-bromo-4-chloro-6-[（4-methylpyridin-2-ylimino）methyl]phenol （C13H10BrClN20）, has been synthesized by the condensation of equimolar 3-bromo-5- chlorosalicylaldehyde and 4-methylpyridin-2-ylamine in a methanol solution. The compound was characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group P21 with a = 6.048（3）, b = 14.063（7）, c = 7.623（4） A,β = 97.703（7）°, Z = 2, V = 642.5（6）A3, Dc = 1.683 g/cm3, Mr=325.59, 2（MoKa） = 0.71073A,μ = 3.395 mm^-1, F（000） = 324, R = 0.0370 and wR = 0.0662. A total of 3879 reflections were collected, of which 1970 with I 〉 2σ（I） were observed. As expected, the molecule adopts a trans configuration about the C=N double bond. The benzene and pyridine rings are nearly coplanar （mean deviation from the combined plane is 0.031（3）A）, with their dihedral angle of 3.3（3）°. The preliminary biological tests show that the compound has excellent antibacterial activities.