| A Novel Oxidative N-Demethylation of 12-Membered Macrolide with Lead Tetraacetate |
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| 作者姓名： | Wei Ge ZHANG Ying Hua JIN Ping QI Kai BAO Jin Guang LIN Nai Li WANG Xin Shen YAO |
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| 作者单位： | Wei Ge ZHANG1，2，Ying Hua JIN3，Ping QI3，Kai BAO1，Jin Guang LIN1，Nai Li WANG2，Xin Shen YAO2 1School of Pharmaceutical Engineering，Shenyang Pharmaceutical University，Shenyang 110016 2The Research Center of Traditional Chinese Medicines and Natural Products，Research Institute of Tsinghua University，Shenzhen 518057 3Department of Pharmacy，General Hospital of Beijing Military Command，Beijing 100003 |
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| 基金项目： | We gratefully acknowledged the financial support of the Liaoning Bureau of Science ＆ Technology （20021028）, Liaoning Bureau of Education （202043238） and the Shenyang Bureau of Science ＆ Technology （02Z01060）. |
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| 摘 要： | Erythromycin has been extensively used in the treatment of bacterial infections for over 50 years1. In addition to the antimicrobial effect, the quite unique antiinflammatory activity of the erythromycin derivatives has attracted much attention as new the…
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| 关 键 词： | 氧化N-脱甲基 12-大环内酯 四乙酸酯 二氯甲 催化系统 |
| 收稿时间： | 2005-04-04 |
A Novel Oxidative N-Demethylation of 12-Membered Macrolide with Lead Tetraacetate |
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| Wei Ge ZHANG Ying Hua JIN Ping QI Kai BAO Jin Guang LIN Nai Li WANG Xin Shen YAO.A Novel Oxidative N-Demethylation of 12-Membered Macrolide with Lead Tetraacetate[J].Chinese Chemical Letters,2006,17(1):9-11. |
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| Authors: | Wei Ge ZHANG Ying Hua JIN Ping QI Kai BAO Jin Guang LIN Nai Li WANG Xin Shen YAO |
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| Abstract: | Reaction of 12-membered macrolide 1 with lead tetraacetate in dichloromethane afforded an unexpected, novel oxidative N-demethyl product 3. |
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| Keywords: | Oxidative N-demethylation 12-membered macrolide lead tetraacetate |
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