Regioselective Synthesis and Properties of 6-Amino-3-carbamoyl-5-cyano-3,4-dihydrospirocyclohexane-4-pyridine-2-thiol and 5-Cyano-3-thiocarbamoyl-4-spirocyclohexanepiperidine-2,6-dione |
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| Authors: | A. D. Dyachenko S. M. Desenko V. D. Dyachenko |
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| Affiliation: | (1) Taras Shevchenko State Pedagogical University, Lugansk, 91011, Ukraine;(2) V. N. Karazin Kharkov National University, Kharkov, 61070, Ukraine |
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| Abstract: | ![]()
Treatment of monothiomalonodiamide with cyclohexylidenemalononitrile or cyclohexylidenecyanoacetic ester in the presence of sodium ethylate gave 6-amino-3-carbamoyl-5-cyano-3,4-dihydrospirocyclohexane-4-pyridine-2-thiol and 5-cyano-3-thiocarbamoyl-4-spirocyclohexanepiperidine-2,6-dione. Their alkylation and hydrolysis have been studied. |
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| Keywords: | 3,4-dihydrospirocyclohexane-4-pyridine-2-thiol monothiomalonodiamide spirocyclohexane-4-piperidine-2,6-dione cyclohexylidenemalononitrile cyclohexylidenecyanoacetic ester alkylation hydrolysis Michael reaction regioselective synthesis cyclization cyclocondensation |
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