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Shape and size of giant unilamellar phospholipid vesicles containing cardiolipin
Authors:Tomsiè Nejc  Babnik Blaz  Lombardo Darko  Mavcic Blaz  Kanduser Masa  Iglic Ales  Kralj-Iglic Veronika
Affiliation:Faculty of Medicine, University of Ljubljana, Vrazov trg 2, Ljubljana, Slovenia.
Abstract:
The effect of cardiolipin content on the shape and size of giant palmitoyloleylphosphatidylcholine/cardiolipin vesicles was studied. Unilamellar vesicles were prepared in sugar solution by the method of electroformation, from mixtures containing up to 50% weight ratio of cardiolipin. At room temperature the vesicles containing cardiolipin exhibited abrupt changes in the curvature of the vesicle contour indicating regions of phase separation. The deviations from the spherical shape were larger if vesicles were made from mixtures with a higher content of cardiolipin. Numerous vesicles with soft fluctuating walls were observed. The estimated size of the vesicles containing cardiolipin was found to be smaller than the size of pure palmitoyloleylphosphatidylcholine vesicles.
Keywords:
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