| 双功能金属锌(Salen)配合物催化的醛的不对称炔基加成反应 |
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| 引用本文： | 沈淳.,陈磊,汤杰,徐明华.双功能金属锌(Salen)配合物催化的醛的不对称炔基加成反应[J].中国化学,2009,27(2):413-418. |
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| 作者姓名： | 沈淳. 陈磊 汤杰 徐明华 |
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| 作者单位： | 1.华东师范大学化学系，中山北路3663号，上海200062
2.中国科学院上海药物研究所，祖冲之路555号，上海201203 |
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| 摘 要： | 本文研究了双功能金属锌(Salen)配合物催化的醛的不对称炔基加成反应。在相应的反应中，当手性salen配体的C3和C3’位有路易斯碱性的1-哌啶甲基取代时，其和金属锌形成的配合物较一般的锌(Salen)配合物具有更好的催化活性和立体选择性。
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| 关 键 词： | 不对称 炔基化 双功能催化剂 salen |
| 收稿时间： | 2008-8-14 |
| 修稿时间： | 2008-9-25 |
Asymmetric Alkynylation of Aldehydes Catalyzed by Bifunctional Zinc(salen) Complex |
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| Chun SHEN,Lei CHEN,Jie TANG,Minghua XU.Asymmetric Alkynylation of Aldehydes Catalyzed by Bifunctional Zinc(salen) Complex[J].Chinese Journal of Chemistry,2009,27(2):413-418. |
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| Authors: | Chun SHEN Lei CHEN Jie TANG Minghua XU |
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| Institution: | 1. Department of Chemistry, East China Normal University, 3663 Zhongshan Road, Shanghai 200062, China;2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China |
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| Abstract: | The asymmetric alkynylation of aldehydes catalyzed by bifunctional Zn(salen) catalyst was realized. With a Kozlowski salen ligand (7e) bearing secondary basic 1‐piperidinylmethyl groups at C‐3 and C‐3′, the enhanced catalytic reactivity and stereoselectivity in comparison with that of normal salen ligands in the alkynylzinc addition to aldehydes were observed. |
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| Keywords: | asymmetric alkynylation bifunctional catalyst salen |
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