| pH响应的磁共振成像造影剂的研究进展 |
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| 引用本文： | 孙晓明,唐建斌,隋梅花,申有青.pH响应的磁共振成像造影剂的研究进展[J].化学通报,2012(1):21-26. |
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| 作者姓名： | 孙晓明 唐建斌 隋梅花 申有青 |
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| 作者单位： | 浙江大学化学工程与生物工程学系化学工程联合国家重点实验室生物纳米工程中心 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)项目(2009CB526403);国家自然科学基金项目(20904046);浙江省“钱江人才计划”项目(2010R10050);教育部博士基金项目(20090101120159)资助 |
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| 摘 要： | pH响应的磁共振成像(MRI)造影剂不仅能够对病变部位进行特异性增强成像,提高MRI检测疾病的灵敏度,而且可通过检测病变组织中的pH变化,为疾病的诊断提供依据。本文综述了pH响应的MRI造影剂的研究进展,介绍了其pH响应机理、种类与结构及应用,并对它的发展前景做了展望。
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| 关 键 词： | 磁共振成像 造影剂 钆配合物 pH响应 疾病诊断 |
Progress in pH-Responsive Magnetic Resonance Imaging Contrast Agents |
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| Sun Xiaoming,Tang Jianbin,Sui Meihua,Shen Youqing.Progress in pH-Responsive Magnetic Resonance Imaging Contrast Agents[J].Chemistry,2012(1):21-26. |
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| Authors: | Sun Xiaoming Tang Jianbin Sui Meihua Shen Youqing |
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| Institution: | (Center for Bio-nano-engineering and the State Key Laboratory for Chemical Engineering,Departmentof Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027) |
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| Abstract: | pH-responsive magnetic resonance imaging(MRI) contrast agents are able to not only increase the sensitivity of disease detection by specifically enhancing the MRI of pathologic tissues,but also assist disease diagnosis by measuring altered pH in diseased tissues.In this paper,the mechanism,classification,structures,applications and progress of pH-responsive contrast agents were reviewed. |
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| Keywords: | Magnetic Resonance Imaging Contrast agent Gadolinium complexes pH-responsive Pathology diagnosis |
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