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Synthesis and biological evaluation of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates against Eimeria tenella |
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| Authors: | Yuan Yuan Zhang Xing Yan Zeng Kui Nie Zhi Cheng Zhong Yu Liang Wang Yu Zhong Wang |
| Institution: | a Department of Chemical Engineering, Sichuan University, Chengdu 610065, China;b College of Animal Science and Technology, Southwest University, Chongqing 400715, China;c Department of Chemistry, Sichuan University, Chengdu 610064, China |
| Abstract: | A series of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates were designed and synthesized.Their structures were confirmed by 1H NMR,13C NMR,IR and HRMS.The biological activities were primarily evaluated against Eimeria tenella according to Anticoccidial Index(ACI)method in vivo.The results showed that compounds 5e,5f and 5i exhibited anticoccidial activities against E.tenella at 27 mg kg-1. |
| Keywords: | Ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylate Synthesis Anticoccidial activity Eimeria tenella |
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