| Design, Synthesis and Investigation of Bone Affinity of the Conjugates of 5-Fluorouracil and Hydroxybisphosphonate |
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| 作者姓名： | Liu Hua XU Hu ZHENG Ling Ling WENG |
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| 作者单位： | West China School of Pharmacy, Sichuan University, Chengdu 610041 |
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| 基金项目： | This work was financially supported by the National Ministry of Science and Technology of China （project No. 2004CB518800）. |
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| 摘 要： | Bone tumor, as a common disease, is treated by surgical resection, radiotherapy and chemotherapy. Chemotherapy is one of the most important treatment, however, a major problem of chemotherapy is lack of selectivity of cytotoxic drugs. Although many attempts have been made to increase the selectivity of therapeutic drugs for the bone diseases, such as osteoporosis, paget’s, hypercalcemia and bone metastases by conjugating them with targeting carriers1-4, there are still no bone-targeting agent…
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| 关 键 词： | 氟二氧嘧啶 羟基磷灰石 骨瘤 化学疗法 合成方法 |
| 收稿时间： | 2005-03-16 |
Design, Synthesis and Investigation of Bone Affinity of the Conjugates of 5-Fluorouracil and Hydroxybisphosphonate |
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| Liu Hua XU Hu ZHENG Ling Ling WENG.Design, Synthesis and Investigation of Bone Affinity of the Conjugates of 5-Fluorouracil and Hydroxybisphosphonate[J].Chinese Chemical Letters,2005,16(11):1434-1436. |
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| Authors: | Liu;Hua;XU;Hu;ZHENG;Ling;Ling;WENG |
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| Abstract: | A series of novel bone-targeting antitumor agents-the conjugates of 5-fluorouracil and hydroxybisphosphonate were designed and synthesized their structures were confirmed by ^1H-NMR, ^13C-NMR, ^31P-NMR, MS, and element analysis. The tests of bone-targeting activity show that these compounds have an obvious affinity for bone. |
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| Keywords: | 5-Fluorouracial hydroxybisphosphonate bone-targeting conjugate hydroxyapatide |
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