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Wickerols A and B: novel anti-influenza virus diterpenes produced by Trichoderma atroviride FKI-3849 |
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| Authors: | Tsuyoshi YamamotoNaoyuki Izumi Hideaki Ui Akito SuekiRokuro Masuma Kenichi NonakaTomoyasu Hirose Toshiaki Sunazuka Takayuki Nagai Haruki Yamada Satoshi ōmura Kazuro Shiomi |
| Institution: | a Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan b Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan |
| Abstract: | Wickerols A and B were produced by a fungus, Trichoderma atroviride FKI-3849. Wickerol A showed potent anti-influenza virus activity against strain A/PR/8/34 (H1N1), whereas wickerol B exhibited weaker impact. The anti-influenza virus spectrum between wickerols A and B was different. The cyclization mechanism of the wickerol carbon-skeleton was investigated by incorporation of 13C-labeled acetate. A pathway through the verticillyl cation was predicted. |
| Keywords: | Wickerol Anti-influenza virus Diterpene Trichoderma atroviride |
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