可生物降解聚合物药物释放数学模拟研究进展

由于可降解的聚合物作为药物载体可以使得药物释放具有较高的靶向性、药物释放更加平缓 ,特别是可以使一些不稳定、半衰期短的药物在人体内达到可控制释放的效果 ,因此将可降解聚合物应用于药物释放体系中作为药物载体得到了较深入的研究。随着研究的深入 ,通过数学方法模拟或预测聚合物载体的降解过程以及聚合物降解过程中药物的释放行为是控释体系设计与应用的一个重要发展方向。由于影响因素较多 ,将所有因素逐一考虑将使得数学模型过于庞杂而失去实际意义 ,所以一个数学模型通常只考虑最主要几个的影响因素 ,并对药物释放系统进行相应的假设。目前文献中报道的降解 (溶蚀 )控制药物释放体系的数学模型大致可以分为两类 :假设药物释放按照零级过程 (zeroorderprocess)进行的经验模型和考虑影响药物释放的多种物理化学过程(如局部传质、化学反应 )的理论模型。本文综述了这些理论模型及其研究进展

Review of Mathematical Modeling of Biodegradable Polymeric Drug Delivery System

Since bioerodible polymers may lead targetable and prolonged drug releasing behavior, especially for the drugs which are highly unstable and have short half-life in vivo, bioderodible polymers were widely investigated recently. One of the important directions of designing controlled drug delivery system with bioerodible polymer matrix is using mathematical approaches to simulate or predict the drug releasing behavior. Due to numerous mass transport phenomena and chemical reactions would influence the drug releasing, it would not be reasonable to take all these factors into account. Generally, one mathematical model would only consider several crucial parameters and assume that drug releasing would follow some kinetics. There are mainly two categories of mathematical models: Empirical Models which assume drug release follows zero order process kinetics and Mechanistic Models which consider the influence of chemical and physical phenomena. The aim of this article is to give an introduction of these models and the relating researching progress.