Formation of the same pyrimido[1,2-a]indoles from 1-(oxiran-2-ylmethyl)-1H-indole or [1,3]oxazolo[3,2-a]indole derivatives in its reactions with aromatic amines |
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| Authors: | Konstantin F Suzdalev Sophia V Den'kina Valerii V Tkachev |
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| Institution: | 1. Chemical Department of Southern Federal University, Zorge Street 7, 344090 Rostov-on-Don, Russian Federation;2. Institute of Problems of Chemical Physics, Russian Academy of Sciences, N.N. Semyonov Street 1, 142432 Czernogolovka, Moscow Region, Russian Federation |
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| Abstract: | Reactions of two isomers—2-chloro-1-(oxiran-2-ylmethyl)-1H-indole-3-carbaldehyde or 2-(chloromethyl)-2,3-dihydro1,3]oxazolo3,2-a]indole-9-carbaldehyde with aromatic amines lead to the same products in both cases—hydrochlorides of pyrimido1,2-a]indole derivatives containing two fragments of an amine per one part of the indole nucleus. Its structure was confirmed by X-ray analysis of the crystals base, obtained by alkali treatment of the reaction product (when aryl is 4-MeOC6H4). |
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| Keywords: | Indole Oxiran [1 3]Oxazolo[3 2-a]indole Recyclization Pyrimido[1 2-a]indoles |
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