Investigation of the scope and mechanism of copper catalyzed regioselective methylthiolation of aryl halides |
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| Authors: | PJ Amal Joseph S PriyadarshiniM Lakshmi Kantam B Sreedhar |
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| Institution: | Inorganic and Physical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500607, India |
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| Abstract: | Methylthiolation of structurally diverse aryl halides was accomplished under fluoride free conditions using catalytic amounts of CuI, and DMSO as the methylthiolation source. Optimization studies unveiled several varieties of promoters among which Zn(OAc)2 was found ideal. The analogous reaction with DMSO-d6 afforded corresponding deuterated aryl methyl thioether with 99% purity. Mechanistic studies revealed CuSMe as the active methylthiolation agent. |
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| Keywords: | Methylthiolation Aryl halides Aryl sulfides CuSMe Catalysis |
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