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A strategy to access fused triazoloquinoline and related nucleoside analogues |
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| Authors: | Kapil Upadhyaya Arya Ajay Rohit Mahar Renu Pandey Brijesh Kumar Sanjeev K. Shukla Rama Pati Tripathi |
| Affiliation: | 1. Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow 226001, India;2. Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226001, India;3. Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Lucknow 226001, India |
| Abstract: | Fused triazoloquinolines have been prepared starting from (E)-3-(2-nitrophenyl)-1-aryl-prop-2-en-1-ones and sugar or benzyl azides in a sequential [3+2] cycloaddition reaction, followed by one pot Pd–C assisted reduction, cyclization and aromatization. The triazolyl fused quinolines with N1-glycosyl substituents as unnatural nucleosides have inherent potential to generate a library of compounds for bioevaluations. |
| Keywords: | Cycloaddition Reductive cyclization Triazoloquinolines Unnatural nucleoside |
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