基于壳聚糖的纳米药物传递体系

壳聚糖作为天然高分子材料,不仅安全无毒、而且具有良好的生物相容性、可生物降解性等优点,在药物传递领域作为纳米载体倍受关注。壳聚糖基纳米载体材料制备条件简单温和,近年来,其相关研究也颇为新颖。本文以载体形成的驱动力作为切入点,从共价交联、离子相互作用、聚电解质络合物和疏水改性四个方面,总结不同种类壳聚糖基纳米载体的构筑方法,同时介绍该载体对药物传递中载药量、载药率、释放行为以及细胞毒性等方面的影响,在此基础上展望其未来的应用前景。

Chitosan-based Nanocarriers for Drug Delivery

As a nature polymer,chitosan has been attracted more and more attention in drug delivery systems because of its outstanding properties,such as non-toxic,biodegradable and biocompatible.Chitosan based nanocarriers can be prepared easily,and recently,the researches of these nanocarries are very novel too.On the basis of the propulsion to formulate nanocarriers,the review is to summerize the latest preparation of modified chitosan derivatives from four aspects:covalent crosslinking,ionic crosslinking,polyelectrolyte complex,and the self-assembly of hydrophobically modi?ed chitosan.And the review is to introduce the effect on drug delivery of drug loading content,drug loading efficiency,release behavior and cytotoxicity,furthermore,outlook the future application.