|
|||||
|
|
| Comparative molecular field analysis (CoMFA) of new herbicidal sulfonylurea compounds | |
| 引用本文： | 刘洁,李正名,王霞,马翼,赖城明,贾国锋,王玲秀. Comparative molecular field analysis (CoMFA) of new herbicidal sulfonylurea compounds[J]. 中国科学B辑(英文版), 1998, 41(1): 50-53. DOI: 10.1007/BF02875556 |
| 作者姓名： | 刘洁 李正名 王霞 马翼 赖城明 贾国锋 王玲秀 |
| 作者单位： | Elemento|Organic Chemistry Institute，State Key Laboratory of Elemento|Organic Chemistry，Nankai University，Tianjin 300071，China |
| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (GrantedNo .2 9772 6 79)andtheStateKeyLabora toryofElemento OrganicChemistry |
| 摘 要： | Ｓｕｌｆｏｎｙｌｕｒｅａｈｅｒｂｉｃｉｄｅｓｈａｖｅｂｅｅｎｕｓｅｄｆｏｒｓｅｖｅｒａｌｄｅｃａｄｅｓ,ｗｈｉｃｈｐｏｓｓｅｓｓｕｌｔｒａｌｏｗｄｏｓａｇｅ,ｌｏｗｍａｍｍａｌｉａｎｔｏｘｉｃｉｔｙａｎｄｄｅｓｉｒａｂｌｅｅｎｖｉｒｏｎｍｅｎｔａｌｐｒｏｐｅｒｔｉｅｓ.ＴｈｅｙｋｉｌｌｗｅｅｄｓｂｙｉｎｈｉｂｉｔｉｎｇｔｈｅａｃｔｉｖｉｔｙｏｆＡＬＳｅｎｚｙｍｅｏｆｔｈｅｗｅｅｄｓａｎｄｄｅｓｔｒｏｙｉｎｇｔｈｅｓｙｎｔｈｅｓｉｓｏｆｂｒａｎｃｈｃｈａｉｎａｍｉｎｏａｃｉｄ.Ｓｉｎｃｅｔｈｅｅｓｔａ… |
| 收稿时间： | 1997-06-11 |
Comparative molecular field analysis (CoMFA) of new herbicidal sulfonylurea compounds |
|
| Jie Liu,Zhengming Li,Xia Wang,Yi Ma,Chengming Lai,Guofeng Jia,Lingxiu Wang. Comparative molecular field analysis (CoMFA) of new herbicidal sulfonylurea compounds[J]. Science in China(Chemistry), 1998, 41(1): 50-53. DOI: 10.1007/BF02875556 | |
| Authors: | Jie Liu Zhengming Li Xia Wang Yi Ma Chengming Lai Guofeng Jia Lingxiu Wang |
| Affiliation: | (1) Elemento-Organic Chemistry Institute, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, 300071 Tianjin, China |
| Abstract: | A series of new herbicidal sulfonylurea compounds were investigated aiming at developing a three dimensional quantitative structure activity relationship (3D QSAR) model using the CoMFA technique. On this base, some molecular structures were modified to improve their activities. A model of the target acetolactate syntheses (ALS) enzyme was established for the first time, which is useful to design and synthesis of new ALS enzyme inhibitor. |
| Keywords: | CoMFA 3D QSAR ALS enzyme herbicidal sulfonylurea |
| 本文献已被 CNKI SpringerLink 等数据库收录！ | |