<Emphasis Type="Italic">Lactobacillus plantarum</Emphasis> AS1 Isolated from South Indian Fermented Food <Emphasis Type="Italic">Kallappam</Emphasis> Suppress 1,2-Dimethyl Hydrazine (DMH)-Induced Colorectal Cancer in Male Wistar Rats |
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Authors: | R Satish Kumar P Kanmani N Yuvaraj K A Paari V Pattukumar C Thirunavukkarasu V Arul |
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Institution: | (1) Department of Biotechnology, School of Life Sciences, Pondicherry University, Pondicherry, 605014, India;(2) Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry, 605014, India; |
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Abstract: | The relationship between antioxidant and anticancer properties of probiotic bacterium strain Lactobacillus plantarum AS1 (AS1) in colon cancer induced by 1,2-dimethylhydrazine (DMH) has been studied. In this study, an increased level of lipid
peroxide (LPO) products and increased activities of antioxidant enzymes (superoxide dismutase, catalase and glutathione-S transferase) and marker enzymes (alkaline phosphatase and acid phosphatase) in colon and plasma of cancer-bearing animals
have been observed. AS1 was supplemented either before initiation or during initiation and selection/promotion phases of colon
carcinogenesis and was found to be effective in altering lipid peroxidation and antioxidant enzyme activities and marker enzymes
to a statistically significant level measured either in the colon and in the plasma. These alterations inclined towards normal
in a time-dependent manner on AS1 supplementation. The mean tumor volume diameter and total number of tumors were found to
be statistically decreased in AS1 pre- and post-treated rats. Furthermore, histopathological examination shows remarkable
difference between control and treated groups. The in vitro antioxidant assay shows that AS1 has promising antioxidant property.
These results demonstrate that AS1 strain can modulate the development of DMH-induced rat colon carcinogenesis through an
antioxidant-dependent mechanism. |
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