Increasing the solubility characteristics of fenofibrate with cyclodextrin |
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Authors: | Zoltán Aigner Ingrid Bencz Michael Kata |
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Institution: | (1) Department of Pharmaceutical Technology, Albert Szent-Györgyi Medical University, P.O. Box 121, H-6701 Szeged, Hungary |
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Abstract: | The incidence of genetic lipoprotein disorders, or hyperlipoproteinaemia, is currently increasing. Examinations were carried out on the hyperlipoproteinaemic drug fenofibrate and various cyclodextrin derivatives were applied to increase the solubility of this drug. Numerous products with several compositions (drug: CD mole ratio=2:1, 1:1, 1:2 or 1:3) were studied and three preparation methods (powder mixing, kneading and precipitation) were used. In vitro drug liberation and membrane diffusion examinations revealed compositions suitable for the preparation of a capsule dosage form (1:2 and 1:3 physical mixtures).Dedicated to Dr. Béla Selmeczi, university professor, with the best wishes for his 65th birthday. |
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Keywords: | Cyclodextrins DIMEB fenofibrate mixing kneading precipitation increase of solubility characteristics membrane diffusion |
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