| Prediction of affinities of peptides for calmodulin |
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| 作者姓名： | 阎虎生 倪爱国 刘利平 程晓辉 何炳林 |
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| 作者单位： | Institute of Polymer Chemistry，Nankai University，Tianjin 300071，China，Institute of Polymer Chemistry，Nankai University，Tianjin 300071，China，Institute of Polymer Chemistry，Nankai University，Tianjin 300071，China，Institute of Polymer Chemistry，Nankai University，Tianjin 300071，China，Institute of Polymer Chemistry，Nankai University，Tianjin 300071，China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China |
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| 摘 要： | A simple method has been developed to predict the calmodulin-binding domains of peptides and the affinities of the peptides for calmodulin based on a model for the calmodulin-binding domains of peptides proposed in a previous paper and the literature data of calmodulin-binding peptides. The effects of hydrophobitities, α-helix-forming tendencies, and basicities of peptides on their affinities for calmodulin were studied. Model peptides were designed to examine the calmodulin-binding domain model and the prediction method. The determined dissociation constants of the complexes formed from the model peptides and calmodulin are in good agreement with the predicted results.
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Prediction of affinities of peptides for calmodulin |
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| YAN Husheng,NI Aiguo LIU LipingCHENG Xiaohui and HE Binglin.Prediction of affinities of peptides for calmodulin[J].Science in China(Chemistry),1996(2). |
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| Authors: | YAN Husheng NI Aiguo LIU LipingCHENG Xiaohui and HE Binglin |
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| Abstract: | |
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| Keywords: | calmodulin peptide binding |
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