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A low-cost automated flow analyzer based on low temperature co-fired ceramic and LED photometer for ascorbic acid determination |
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| Authors: | Osmundo D Pessoa-Neto Vagner B dos Santos Fernando C Vicentini Willian T Suarez Julián Alonso-Chamarro Orlando Fatibello-Filho Ronaldo C Faria |
| Institution: | 1. Chemistry Department, Center of Exact Sciences and Technology, Federal University of S?o Carlos, 13565-905, S?o Carlos-SP, Brazil 2. Chemistry Department, Exact and Technological Sciences Center, Federal University of Vi?osa, 36570-000, Vi?osa-MG, Brazil 3. Group of Sensors and Biosensors, Department of Chemistry, Autonomous University of Barcelona, Edifici Cn, 08193, Bellaterra, Spain |
| Abstract: | An automated flow analyzer based on low temperature co-fired ceramic (LTCC), a solid-phase reactor (SPR) and a low-cost photometer was designed for ascorbic acid (AA) determination in pharmaceutical formulations. It consists of a peristaltic pump, three-way solenoid valves, SPR to chemically convert Cu(II) into Cu(I), and a LTCC device for mixing the liberated copper with bathocuproine and detection. The flow cell in the LTCC employed an ultrabright LED — photodiode photometer. The analyzer successfully determined AA in pharmaceutical formulations. The analytical curve from 8.5×10?6 to 7.0×10?4 M gave a detection limit of 7.0×10?7 M and a RSD of 2.1% for a 2.0×10?4 M AA solution (n = 10). A high sampling frequency of 102 h?1 and low reagent and sample consumption (150 µL) resulted. |
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