| 流动注射-共振瑞利散射法测定盐酸氯丙嗪和盐酸异丙嗪 |
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| 引用本文： | 陈佩丽,刘绍璞,刘忠芳,胡小莉.流动注射-共振瑞利散射法测定盐酸氯丙嗪和盐酸异丙嗪[J].分析化学,2010,38(7). |
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| 作者姓名： | 陈佩丽 刘绍璞 刘忠芳 胡小莉 |
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| 作者单位： | 发光与实时分析教育部重点实验室,西南大学化学化工学院,重庆,400715 |
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| 基金项目： | 国家自然科学基金，发光与实时分析重庆市重点实验项目 |
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| 摘 要： | 在HCl介质中,12-钨磷酸(TP)分别与盐酸氯丙嗪(CPZ)和盐酸异丙嗪(PMZ)反应形成离子缔合物,导致溶液的共振瑞利散射(RRS)显著增强,并产生新的RRS光谱.它们的最大RRS峰位于359 nm (TP-CPZ)和346 nm (TP-PMZ),并且在一定范围内,CPZ和PMZ的浓度与散射强度呈线性关系,据此提出流动注射-共振瑞利散射 (FIA-RRS) 联用技术测定CPZ和PMZ的新方法,CPZ和PMZ的检出限分别为1.7和3.0 μg/L.实验优化了流动注射(FIA)参数和反应条件,并以灵敏度较高的CPZ为例,考察了共存物质的影响.本方法具有良好的选择性和重复性;用于药片和猪肝中CPZ的测定,结果满意.
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| 关 键 词： | 流动注射-共振瑞利散射技术 盐酸氯丙嗪 盐酸异丙嗪 12-钨磷酸 |
Determination of Chlorpromazine Hydrochloride and Promethazine Hydrochloride by Resonance Rayleigh Scattering Method Coupled with Flow Injection Technique |
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| CHEN Pei-Li,LIU Shao-Pu,LIU Zhong-Fang,HU Xiao-Li.Determination of Chlorpromazine Hydrochloride and Promethazine Hydrochloride by Resonance Rayleigh Scattering Method Coupled with Flow Injection Technique[J].Chinese Journal of Analytical Chemistry,2010,38(7). |
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| Authors: | CHEN Pei-Li LIU Shao-Pu LIU Zhong-Fang HU Xiao-Li |
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| Institution: | CHEN Pei-Li,LIU Shao-Pu,LIU Zhong-Fang,HU Xiao-Li (Key Laboratory on Luminescence and Real-Time Analysis,Ministry of Education,School of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715) |
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| Abstract: | In HCl medium with pH 1.0,12-tungstophosphori acid (TP) reacted with chlorpromazine hydrochloride (CPZ) or promethazine hydrochloride (PMZ) to form ion-association complexes,respectively,which resulted in significant enhancement of the resonance Rayleigh scattering (RRS) intensity.The maximum peaks were located at 359 nm (TP-CPZ) and 346 nm (TP-PMZ).In a certain range,the RRS intensity was proportional to the concentration of CPZ or PMZ.Based on it,a flow injection analysis (FIA) coupled to resonance Raylei... |
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| Keywords: | Flow injection analysis Resonance Rayleigh scattering Chlorpromazine hydrochloride Promethazine hydrochloride 12-Tungstophosphoric acid |
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