A novel high selective and sensitive metronidazole voltammetric sensor based on a molecularly imprinted polymer-carbon paste electrode |
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Authors: | Gholivand Mohammad Bagher Torkashvand Maryam |
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Institution: | Department of Analytical Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran |
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Abstract: | The design and construction of a highly selective voltammetric sensor for metronidazole by using a molecularly imprinted polymer (MIP) as recognition element were introduced. A metronidazole selective MIP and a nonimprinted polymer (NIP) were synthesized and then incorporated in the carbon paste electrodes (CPEs). The sensor was applied for metronidazole determination using cathodic stripping voltammetric method. The MIP-CP electrode showed very high recognition ability in comparison to NIP-CPE. Some parameters affecting the sensor response were optimized and then the calibration curve was plotted. Two dynamic linear ranges of 5.64 × 10−5 to 2.63 × 10−3 mg L−1 and 2.63 × 10−3 to 7.69 × 10−2 mg L−1 were obtained. The detection limit of the sensor was calculated as 3.59 × 10−5 mg L−1. This sensor was used successfully for metronidazole determination in biological fluids. |
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Keywords: | Metronidazole Molecularly imprinted polymer Cathodic stripping voltammetry Carbon paste |
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