| 季铵盐高分子抗菌剂的工艺优化与抗菌性能研究 |
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| 引用本文： | 董卫民,左华江,吴丁财,符若文.季铵盐高分子抗菌剂的工艺优化与抗菌性能研究[J].离子交换与吸附,2011,27(1). |
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| 作者姓名： | 董卫民 左华江 吴丁财 符若文 |
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| 作者单位： | 1. 聚合物复合材料及功能材料教育部重点实验室中山大学化学与化学工程学院,广州,510275;新型聚合物材料设计合成与应用广东省高校重点实验室中山大学化学与化学工程学院,广州,510275
2. 聚合物复合材料及功能材料教育部重点实验室中山大学化学与化学工程学院,广州,510275 |
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| 基金项目： | 国家自然科学基金项目，广东省科技计划项目 |
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| 摘 要： | 采用正交实验设计,进行公斤级批量制备DMAEMA-DB季铵盐单体和抗菌聚合物的研究,对影响单体合成的关键因素以及聚合的条件进行优化,并采用FT-IR和NMR等方法对所合成的单体和聚合物分别进行了结构表征,通过平板活菌计数法测定了单体以及聚合物的抗菌性能.结果表明,DMAEMA-DB单体的优化合成条件为:反应温度55℃,反应时间30h,反应物浓度为V<,s>:V<,l>=1:1,反应物配比为DMAEMA:DB=1:1.1.Poly(AAm/DMAEMA-DB)的最佳合成工艺条件为:聚合温度70℃,聚合时间8h,单体浓度为0.4mol/L,引发剂用量为单体用量的0.4mol%,在该条件下合成的聚合物平均得率达89%.将它们用于杀灭大肠杆菌时,接触时间5min对大肠杆菌的抑菌率可达99%,接触时间30min抑菌率达到100%.
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| 关 键 词： | 季铵盐 抗菌高分子 工艺优化 抗菌性能 |
OPTIMUM SYNTHESIS OF POLYMERIC ANTIBACTERIAL QUATERNARY AMMONIUM SALT AND STUDIES ON THEIR ANTIBACTERIA PROPERTY |
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| DONG Weimin,ZUO Huajiang,WU Dingcai,FU Ruowen.OPTIMUM SYNTHESIS OF POLYMERIC ANTIBACTERIAL QUATERNARY AMMONIUM SALT AND STUDIES ON THEIR ANTIBACTERIA PROPERTY[J].Ion Exchange and Adsorption,2011,27(1). |
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| Authors: | DONG Weimin ZUO Huajiang WU Dingcai FU Ruowen |
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| Institution: | DONG Weimin1,2 ZUO Huajiang1,2 WU Dingcai1 FU Ruowen1* 1.PCFM Lab,School of Chemistry and Chemical Engineering,Sun Yat-Sen University,Guangzhou 510275 2.DSAPM Lab,Guangzhou 510275 |
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| Abstract: | The preparations of quaternary ammonium salt monomer(DMAEMA-DB) and related antibacterial polymer in kilogram scale were investigated by using orthogonal experimental design.The key conditions which affect on the synthesis of monomer and the related polymerization were optimized.The structures of the monomer and related copolymer produced by us were determined by FT-IR,NMR,and so on.Their antibacterial activities were investigated by a viable cell counting method.The experimental results showed that the opt... |
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| Keywords: | Quaternary ammonium salt Antibacterial polymer Optimization of synthesis conditions Antibacterial property |
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