Direct use of esters in the Mukaiyama aldol reaction: a powerful and convenient alternative to aldehydes |
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| Authors: | Inamoto Yoshihiro Nishimoto Yoshihiro Yasuda Makoto Baba Akio |
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| Affiliation: | Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan. |
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| Abstract: | ![]()
An indium triiodide catalyst promoted the direct transformation from esters to β-hydroxycarbonyl compounds using hydrosilanes and silyl enolates by a one-stage process. Various esters were applicable, and the high chemoselectivity of this system brings compatibility to many functional groups: alkenyl, alkynyl, chloro, and hydroxy. |
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