Multivalent calixarene-based C-fucosyl derivative: a new Pseudomonas aeruginosa biofilm inhibitor |
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| Authors: | Grazia ML ConsoliViviana Cafiso Stefania StefaniCorrada Geraci |
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| Institution: | a Istituto di Chimica Biomolecolare, C.N.R., Via Paolo Gaifami 18, Catania I-95126, Italy
b Dipartimento di Scienze Bio-Mediche Sez. Microbiologia - Università degli Studi di Catania, Via Androne 81, Catania I-95124, Italy |
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| Abstract: | The first example of multivalent conjugate in which four α-l-C-fucosyl units are clustered by means of a calix4]arene platform was designed as a new potential Pseudomonas aeruginosa biofilm inhibitor. The anti-biofilm activity of the synthesized compound (6) against PAO1 strain was assayed and it was found to be dose-dependent. The presence of the fucose cluster improves the biofilm inhibitor efficiency as proven by the lower inhibitor activity of the analogous glycyl-calix4]arene derivative (3) lacking in the fucose moieties. |
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| Keywords: | C-Fucosyl derivative Calixarene Pseudomonas aeruginosa Inhibition biofilm assay Multivalency |
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