A novel class of amide-derived air-stable P,O-ligands for Suzuki cross-coupling at low catalyst loading |
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| Authors: | Wei-Min Dai Yannain Li Kwong Wah Lai |
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| Institution: | a Laboratory of Asymmetric Catalysis and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, China
b Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China |
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| Abstract: | The benzamide-derived P,O-ligands efficiently promoted the Pd-catalyzed Suzuki cross-coupling reactions of aryl bromides with phenylboronic acid at 0.01 mol % of Pd loading at 60-80 °C to form biaryls in excellent yields. A sterically hindered arylboronic acid gave a quantitative yield of the coupling product at 110 °C with 1 mol % Pd. |
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| Keywords: | Amides Phosphines Coupling reactions Aryl bromides |
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