Novel ent-kaurane dimers from Isodon rubescens var. rubescens |
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| Authors: | Quanbin Han Lili Zhang Handong Sun |
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| Institution: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China
b Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, PR China |
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| Abstract: | Three novel asymmetric ent-kaurane dimers xindongnins M-O (1-3) were isolated from Isodon rubescens var. rubescens. Their structures were elucidated by spectroscopic methods including 2D NMR analysis. The relative stereochemistry of 1 was determined by single crystal X-ray diffraction, which also confirmed the unique linkage of a single carbon-carbon bond between the two subunits of this dimer. A biogenetic pathway was proposed for the formation of these dimers. |
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| Keywords: | ent-Kaurane dimer Xindongnins M-O Isodon rubescens var rubescens |
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