Cu(II)-catalyzed enantioselective aldol condensation between malonic acid hemithioesters and aldehydes |
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| Authors: | Simonetta Orlandi |
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| Institution: | Dipartimento di Chimica Organica e Industriale, Universita’ degli Studi di Milano and CNR-ISTM, Via Golgi 19, I-20133 Milano, Italy |
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| Abstract: | A mild, decarboxylative, aldol-type addition of malonic acid hemithioesters to aldehydes has been shown to occur with up to 39% enantioselectivity when the reaction was carried out in the presence of catalytic amounts of a Cu(II) salt, an enantiopure, tartaric acid-derived bis-benzimidazole and an achiral base. |
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| Keywords: | Aldol process Enantioselective catalysis Malonic acid hemithioesters Enantiopure benzimidazoles |
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