Palladium-catalyzed reaction of aryl iodides with <em>tertiary</em> propargylic amides.<span class="articleAltTitle">: Highly substituted allenes through a regioselective carbopalladation/β-NPd elimination reaction</span>期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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*Palladium-catalyzed reaction of aryl iodides with tertiary* propargylic amides.: Highly substituted allenes through a regioselective carbopalladation/β-NPd elimination reaction**

Authors:	Antonio Arcadi Giancarlo Fabrizi Luca M Parisi

Institution:	^a Dipartimento di Chimica Ingegneria Chimica e Materiali della Facoltà di Scienze, Università di L'Aquila, Via Vetoio, Coppito Due, I-67100 L'Aquila, Italy ^b Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università degli Studi “La Sapienza”, P.le A. Moro 5, 00185 Rome, Italy

Abstract:	The palladium-catalyzed reaction of aryl iodides with tertiary propargylic amides affords highly substituted allenes. Best results have been obtained by using Pd(OAc)₂, ⁿBu₃N, HCOOH, and ⁿBu₄NCl or LiCl in DME at 100 °C. The reaction is highly regioselective and the carbopalladation step is controlled by the strong directing effect of the tertiary amide group.

Keywords:	Palladium Allenes Hydroarylation Alkynes
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