Simple entry into isonucleosides: synthesis of 6-amino-9-[(3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl]purine |
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| Authors: | Hari Babu Mereyala Sreeman Kumar Mamidyala |
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| Affiliation: | Speciality, Gas Based Chemicals and Processes Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India |
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| Abstract: | ![]()
A simple and efficient method for the preparation of isonucleoside 7 is described. The preparation of 1,4-anhydroxylitol 4, a key intermediate, is described by intramolecular cyclization of (2S,3R,4R)-3,5-dibenzyloxypentan-1,2,4-triol 3 using diethyl carbonate and NaH. |
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| Keywords: | Isonucleosides Alditol Nucleobase |
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