New solid-supported phosphonate reagents for the synthesis of Z-α,β-unsaturated esters |
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Authors: | Sébastien LX Martina |
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Institution: | Department of Chemistry, University of York, Heslington, York YO10 5DD, UK |
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Abstract: | Novel solid-supported phosphonate reagents have been prepared and evaluated for the synthesis of α,β-unsaturated esters with a preference for the Z-alkene. The optimal reagent was a hybrid of both Still-Gennari and Ando reagents, and showed good to high yields and fair to good Z-selectivity for the conversion of both aliphatic and aromatic aldehydes. |
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Keywords: | Solid supported Ando Still-Gennari Horner-Wadsworth-Emmons |
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