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Peptide synthesis in room temperature ionic liquids |
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| Authors: | Hé lè ne Vallette,Gé rard Coquerel,Jean-Christophe Plaquevent |
| Affiliation: | a UMR-CNRS 6014 de l’IRCOF, Université de Rouen, rue Tesnière, F-76821 Mont Saint Aignan Cedex, France b UPRES-EA 2659, SMS, IRCOF, Université de Rouen, rue Tesnière, F-76821 Mont-Saint Aignan Cedex, France c UMR-CNRS 6507 LCMT, ENSICAEN-ISMRA, Université de Caen, 6 bd du Maréchal Juin, F-14050 Caen, France |
| Abstract: | We demonstrate that chemical peptide coupling using modern coupling agents is efficient in rt ionic liquids. This new approach presents some advantages, especially in the case of hindered amino acids, which are not easy to couple under standard conditions, since high purities for the crude peptides were observed with respect to coupling in classical solvents. |
| Keywords: | Ionic liquids Peptide synthesis Aminoacids |
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