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Simplified chemical and radiochemical synthesis of 2-arachidonoyl-glycerol, an endogenous ligand of cannabinoid receptors |
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| Authors: | Antonella Cartoni Andrea Margonelli Alessandro Finazzi-Agrò |
| Institution: | a Department of Chemical Sciences and Technologies, University of Roma ‘Tor Vergata’, 00168 Rome, Italy b Institute of Nuclear Chemistry, National Council of Research, Monterotondo, Rome, Italy c Department of Experimental Medicine and Biochemical Sciences, University of Roma ‘Tor Vergata’, Rome, Italy d Department of Biomedical Sciences, University of Teramo, Teramo, Italy |
| Abstract: | Endocannabinoids have emerged as a new class of lipid mediators, with manifold roles in the central nervous system and in the periphery. Several studies have identified 2-arachidonoyl-glycerol (2-AG) as a major endogenous agonist of cannabinoid receptors. Here, the chemical synthesis of 2-AG is reported, along with the synthesis of its tritium-labeled derivative. These unlabeled and radiolabeled compounds are suitable tools for unravelling some metabolic routes and biological activities of 2-AG in various cells and tissues. |
| Keywords: | 2-AG 2-arachidonoyl-glycerol [3H]2-AG labeled 2-arachidonoyl-glycerol 1-AG 1-arachidonoyl-glycerol AEA N-arachidonoylethanolamine AA arachidonic acid [3H]AA labeled arachidonic acid |
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