|
|||||
|
|
Preparation of novel analgesics via diastereoselective nucleophilic addition to 1-dimethylamino-2-methylpentan-3-one |
|
| Authors: | Ornella Azzolina Simona Collina Daniela Rossi Enrica Lanza |
| Institution: | a Dipartimento di Chimica Farmaceutica, Università di Pavia, Viale Taramelli 12, 27100 Pavia, Italy b Centro Grandi Strumenti, Università di Pavia, Via Bassi 21, 27100 Pavia, Italy c Dipartimento Farmacologia Sperimentale ed Applicata, Università di Pavia, Viale Taramelli 14, 27100 Pavia, Italy |
| Abstract: | The diastereoselective synthesis of naphthyl amino alcohols via nucleophilic addition to racemic 1-dimethylamino-2-methylpentan-3-one was studied. The use of the appropriate experimental conditions allowed the synthesis of both diastereoisomers. The relative configurations were established via NOESY experiments. |
| Keywords: | Diastereoselective synthesis Chiral aryl amino alcohols Relative configuration |
| 本文献已被 ScienceDirect 等数据库收录！ | |